Suprelorin Product Information
Questions
What conditions does Suprelorin treat?
Male dog: For the induction of temporary infertility in healthy, intact, sexually mature male dogs.
Prepubertal female dog: For the induction of temporary infertility to delay the first oestrus and heat signs, and to prevent pregnancy at a young age in intact and healthy sexually immature female dogs. The implant should be administered between 12 and 16 weeks of age.
Male cat: For the induction of temporary infertility and suppression of urine odour and of sexual behaviours such as libido, vocalisation, urine marking, and aggressiveness in intact male cats from 3 months of age.
How does Suprelorin work?
It contains Deslorelin Acetate given as a subcutaneous implant by your veterinary surgeon.
The GnRH agonist, deslorelin, acts by suppressing the function of the pituitary-gonadal axis when applied in a low, continuous dose. This suppression results in the failure of treated animals, intact or surgically neutered, to synthesise and/or release follicle stimulating hormone (FSH) and luteinising hormone (LH), the hormones responsible for the maintenance of fertility as well as secondary sexual behaviours.
In male dogs or cats, the continuous low dose of deslorelin will reduce the functionality and the size of the male reproductive organs, libido, and spermatogenesis, and lower the plasma testosterone levels, from 4-6 weeks after implantation. A short transient increase in plasma testosterone may be seen immediately after implantation. Measurement of plasma concentrations of testosterone has demonstrated the persistent pharmacological effect of the continuing presence of deslorelin in the circulation for at least six months in dogs and twelve months in cats following administration of the veterinary medicinal product.
In sexually immature female dogs, the continuous low dose of deslorelin maintains dogs in a physiologically immature state and prevents the increase of the plasma oestradiol and progesterone levels. This hormonal downregulation suppresses the development and function of the female reproductive organs and associated sexual heat behavioural signs and changes in vaginal cytology.
How should I administer Suprelorin to my pet?
Your vet will need to administer the implant.
What is the correct dosage of Suprelorin for my animal's weight and species?
The correct dose for your animal is as prescribed and administered by your vet. Your vet will follow the data sheet for the medication prescribed and for some medications will adjust this taking into consideration your animal's medical history.
How long should I continue with Suprelorin for?
You should continue for the length of time your vet prescribed the medication for after discussion with you.If you suspect that your pet may be having an adverse reaction to a medication, please contact your vet for advice on continuing the medication.
What should I do if I miss a dose of Suprelorin?
Not applicable
Where can I buy Suprelorin?
Check that your vet is happy for you to order the medication using a prescription and then for them to administer it. You can purchase Suprelorin cheaper than from your Vet Practice from www.vets4u.uk. To contact vets4u.uk, call us on +44 116 218 4244 between 09:30am and 4:30pm Monday to Friday, chat to us directly or email us at mail@vets4u.uk.
Does Suprelorin need a prescription?
Yes, as it is classified as a POM-V.
How can I buy Suprelorin from Vets4u?
You can buy Suprelorin via our website via a valid prescription by adding to the basket on our website www.vets4u.uk.
You need to check your vet is happy to inject a product which they have not supplied.
Manufacturer’s Link to Suprelorin
NOAH Compendium Datasheet Link to Suprelorin
What are the side-effects of Suprelorin?
All target species: Prepubertal surgical gonadectomy as well as prepubertal hormonal suppression may delay physeal closure in long-bones, typically without clinical or pathological consequences.
Dog (male and female):
Moderate swelling or scabbing at the implant site was commonly observed for 14 days during safety/efficacy studies. Local dermatitis lasting up to 6 months was commonly reported in a field trial.
During the treatment period, rare clinical effects have been reported: Hair coat disorders (e.g. hair loss, alopecia, hair modification), urinary incontinence, down-regulation associated signs (e.g. decrease in testicle size, reduced activity, weight gain) have been reported rarely during the treatment period. A testicle may be able to ascend up through the inguinal ring, in very rare cases. Transitory increased sexual interest, increased testicle size and testicular pain immediately following implantation were reported very rarely. These signs resolved without treatment.
Transient behavioural change with the development of aggression have been reported very rarely.
In humans and animals, sexual hormones (testosterone and progesterone) modulate seizure susceptibility. Epileptic seizures have been observed very rarely and have been reported on average 40 days after implantation, the median time to onset of signs was 14 days after implantation, on the same day of implantation at the earliest, and 36 weeks after implantation at the latest.
Cat:
Local reactions consisting of redness and pain or heat on the day of implantation, that were transient, were commonly observed. Swellings (4 cm) lasting for more than 7 months was reported in 1 out 18 cats in a laboratory study.
Increased sexual activity and roaming may be observed transiently in mature male cats during the first weeks post implantation.
Increased food intake and increase of body weight are known to be associated with neutering. Some treated cats increase their body weight up to 10% during the period of effect.
Can Suprelorin implant be removed?
They can be removed surgically by your vet.
Can Suprelorin be used in cats?
In male cats yes for the induction of temporary infertility and suppression of urine odour and of sexual behaviours such as libido, vocalisation, urine marking, and aggressiveness in intact male cats from 3 months of age.
Suprelorin-v-castration?
If you are considering castration for behaviour reasons Suprelorin can be given to see if surgical castration, rather than repeated injections of the implant, is likely to help. There are always risks with any surgical procedure which you can discuss further with your vet. Consulting a Certified Animal Behaviourist before trying either for behaviour reasons would be sensible. Removing male hormones has been shown to increase anxiety in some male dogs, animal behaviour is complex and you don’t want to make a behaviour issue worse.
Answers Compiled by our RCVS Registered Veterinary Surgeon.