Milbemycin Oxime (A3 and A4), Praziquantel

Form: Film-coated tablet · Pack size: PK 48

Cats

• Legal category: POM-V
• Marketing authorisation holder: KRKA, d.d., Novo mesto Šmarješka cesta 6 8501 Novo mesto Slovenia Further information Pharmacotherapeutic group Endectocides, Macrocyclic lactones, milbemycin, combinations. ATC vet code: QP54AB51 Pharmacodynamic Properties Milbemycin oxime belongs to the group of macrocyclic lactones, isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis. The activity of milbemycin is related to its action on invertebrate neurotransmission: Milbemycin oxime, like avermectins and other milbemycins, increases nematode and insect membrane permeability to chloride ions via glutamate-gated chloride ion channels (related to vertebrate GABAA and glycine receptors). This leads to hyperpolarisation of the neuromuscular membrane and flaccid paralysis and death of the parasite. Praziquantel is an acylated pyrazino-isoquinoline derivative. Praziquantel is active against cestodes and trematodes. It modifies the permeability for calcium (influx of Ca2+) in the membranes of the parasite inducing an imbalance in the membrane structures, leading to membrane depolarisation and almost instantaneous contraction of the musculature (tetany), rapid vacuolization of the syncytial tegument and subsequent tegumental disintegration (blebbing), resulting in easier expulsion from the gastrointestinal tract or death of the parasite. Pharmacokinetic properties In cats under fed condition, praziquantel reaches peak plasma concentrations within 3 hours after oral administration. The half life of elimination is around 2 hours. After oral administration in cats under fed condition, milbemycin oxime reaches peak plasma concentrations within 5 hours. The half life of elimination is around 43 hours (± 21 hours).
• MA number: Milprazon CHEWABLE Tablets for Small Cats and Kittens: Vm 01656/5079 Milprazon CHEWABLE Tablets for Cats: Vm 01656/5080

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